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This diagram illustrates some of the main ways of making electronic annotation. It should be read from the top down. The diagram shows sequences from UniProt having electronic GO annotation assigned by several computational methods. All of these methods involve use of mapping files. To learn more visit the guide to information on mappings of GO to other classification systems .

InterPro Mapping

In the case of the Interpro mapping it is possible to assign electronic GO annotation to your sequences based on InterPro domains and a number of other criteria. For example if your sequence has a DNA binding domain then it makes sense to electronically annotate it to the DNA binding function term. For more information on InterPro mapping please see the information on InterProScan.

UniProt Keyword Mapping

This part of the diagram illustrates how sequences already categorized using the UniProt keyword mapping can have GO annotation automatically applied by transferring via the keyword mapping file.

HAMAP is a system that categorizes sequences based on family or subfamily characteristics and is applied to bacterial, archaeal and plastid-encoded proteins. GO annotation can be automatically applied to such sequences using the mapping file between HAMAP and GO.

Enzyme Commission

The Enzyme Commission database categories enzymes by the reactions they catalyze. If your sequences are already categories by EC then you can transfer GO annotations using the mapping file of EC to GO categories.

Other mappings

These are just a few examples of mapping files that can be used to transfer annotations to your sequence objects. Nike Women’s Downshifter 7 Running Shoes White/Pink Grey Cool Grey/Hyper Violetwolf Grey Black ca5BILT4W
, and if there is not a mapping file between GO and your current annotation system, we can assist you in making one.

You can also make electronic annotations by BLASTing your sequence against manually annotated sequences and transferring the GO annotations across to your sequence. The threshold of similarity in this process is up to you, and depends on your requirements.

No similar sequences manually annotated?

If your sequence is similar to other sequences that have been well characterized but not yet annotated from the literature, then one option is to carry out the Timberland Mens 6 Mono Premium Nubuck Leather LaceUp Boot A1149 Red Green WQc0YRAL
yourself and then transfer by electronic methods .

Literature annotation involves capturing published information about the exact function of a gene product as a GO annotations. To do this you must read the publications about the gene and write down all the information. This annotation is time-consuming but produces very high quality, species-specific annotation, and brings the information about the gene product into a format in which it can be used in high-throughput experiments. This is an extremely worthwhile process in the long term. It may be best carried out by people who know the function of the gene product, and the associated biology, in great detail; for example experimental scientists who are familiar with the published literature. If you are doing this, then you may like to write and suggest modifications to the ontology structure as well.

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August 6, 2012
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BarbyIngle

The difference between anesthesia and tranquilizers August 6, 2012 at 11:25pm Anesthesia vs Tranquilizers

Many people confuse Anesthesia and Tranquilizers so I thought I would research the topic and I learned a few things. My information is from an anesthesiologist, veterinary assistant and wikipedia.

Anesthesia Anesthesia is a state of mindlessness (apathy, loss of sensation, medically induced insensitivity to pain) Anesthesia is much more complex than just “putting out cold” There are 3 fundamental components of a general anesthetic sleep, relief of pain muscle relaxation It is the skill of the Anesthesiologist to match the amount of each component to the particular needs of each patient and each operation The mechanism of action of the anesthetics is one of those ongoing questions, but the most popular theory is that they cause a degree of swelling of the brain cell wall, which obstructs the normal passage of electrolytes in and out of the cell, thereby preventing nerve impulses from being generated An example of a commonly used Anesthesia for humans is Ketamine, Tiletamine, and Propofol Ketamine has also been found to bind to opioid receptors type 2– however, without agonist activity Ketamine interacts with muscarinic receptors, descending monoaminergic pain pathways and voltage-gated calcium channels Ketamine induces a state referred to as “dissociative anesthesia” Ketamine is primarily used for the induction and maintenance of general anesthesia, usually in combination with a sedative. It has been shown to be effective in treating depression in patients with bipolar disorder who have not responded to anti-depressants In persons with major depressive disorder, it produces a rapid antidepressant effect, acting within two hours as opposed to the several weeks taken by typical antidepressants to work It is also a popular anesthetic in veterinary medicine

Tranquilizer/sedatives Tranquility is a state of serenity (calm, stillness, silence) Tranquilizers/sedatives are drugs that may be used in achieving either state, by varying the dose The sedatives can be used for the sleepy bit, but there are several other drugs, including the inhaled anesthetics, which do the same job The sedatives, though being said to make patients relax, do not do the job of a proper muscle relaxant, nor do they do anything to relieve pain Typically drugs are often called sedative/hypnotics due to their ability to cause sedation and induce sleep The primary tranquilizer/sedative in use are benzodiazepines like Valium (Diazepam), Xanax (Alprazolam), Ativan (Lorazepam), Rivotril/Klonopin (Clonazepam), Restoril (Temazepam), Versed/Hypnovel (Midazolam). These drugs are often given for anxiety and/or insomnia

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"It's about the quality of life for your children. Its about your life"

Portugal has announced the world’s first participatory budget on a national scale. The Asics Women’s GelKayano 22 Running Shoes Orange Flash Coral/Carbon/Silver Grey 9Bo6B8
project will let people submit ideas for what the government should spend its money on, and then vote on which ideas are adopted.

Although participatory budgeting has become increasingly popular around the world in the past few years, it has so far been confined to cities and regions, and no country that we know of has attempted it nationwide. To reach as many people as possible, Portugal is also examining another innovation: letting people cast their votes via ATM machines.

For more like this, see our government innovation newsfeed.

‘It’s about quality of life, it’s about the quality of public space, it’s about the quality of life for your children, it’s about your life, OK?’ Graça Fonseca, the minister responsible, told Apolitical. ‘And you have a huge deficit of trust between people and the institutions of democracy. That’s the point we’re starting from and, if you look around, Portugal is not an exception in that among Western societies. We need to build that trust and, in my opinion, it’s urgent. If you don’t do anything, in ten, twenty years you’ll have serious problems.’

Graça Fonseca doing publicity for the participatory budget

Although the official window for proposals begins in January, some have already been submitted to the project’s website. One suggests equipping kindergartens with technology to teach children about robotics. Using the open-source platform Arduino, the plan is to let children play with the tech and so foster scientific understanding from the earliest age.

Proposals can be made in the areas of science, culture, agriculture and lifelong learning, and there will be more than forty events in the new year for people to present and discuss their ideas.

The organisers hope that it will go some way to restoring closer contact between government and its citizens. Previous projects have shown that people who don’t vote in general elections often do cast their ballot on the specific proposals that participatory budgeting entails. Moreover, those who make the proposals often become passionate about them, campaigning for votes, flyering, making YouTube videos, going door-to-door and so fuelling a public discussion that involves ever more people in the process.

A bus is touring the country to raise awareness of the project

On the other side, it can bring public servants nearer to their fellow citizens by sharpening their understanding of what people want and what their priorities are. It can also raise the quality of public services by directing them more precisely to where they’re needed as well as by tapping the collective intelligence and imagination of thousands of participants.

1155 F St NW, Suite 1050, Washington DC, 20004. contact: info@edi-dc.org